Hyperprolactinemia is a frequent neuroendocrinological condition that should be approached in an orderly and integral fashion, starting with a complete clinical history. Once physiological causes such as pregnancy, systemic disorders such as primary hypothyroidism and the use of drugs with dopamine antagonistic actions such as metochlopramide have been ruled out, the most common cause of hyperprolactinemia is a PRL-secreting pituitary adenoma or prolactinoma. Prolactinomas are usually classified as microprolactinomas less than 1 cm or macroprolactinomas larger than 1 cm , which can either be confined or invasive. Macroprolactinomas can also present with symptoms and signs resulting form mass effect of the tumor, such as headaches and visual field defects. Other structural causes of hyperprolactinemia include non-functioning pituitary adenomas and infiltrative disorders, which can interrupt the inhibitory, descending dopaminergic tone. The primary treatment of prolactinomas is pharmacological with dopamine agonists such as cabergoline.
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The authors analyze a series of patients with hyperprolactinemia studied with magnetic resonance imaging M. We have tested several patterns of M. At the same time, we conclude that the use of a paramagnetic contrast agent is mandatory whefi the pre-contrast scan is negative.. If it is the first time you have accessed you can obtain your credentials by contacting Elsevier Spain in suscripciones elsevier.
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Previous article Next article. Issue 1. Pages January Brisa Ferrandis , S. Roch Penderia. This item has received. Article information. Palabras clave:. At the same time, we conclude that the use of a paramagnetic contrast agent is mandatory whefi the pre-contrast scan is negative. Key words:. Member of the society. Subscriber If you already have your login data, please click here.
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2016, Número 1
Biochemical diagnosis of monomeric hyperprolactinemia. Palabras clave: Prolactina. Valores de referencia. Prolactin can take several molecular forms of which the most biologically active is the monomeric form PRLm. The presence of macroprolactin MPRL can give rise to a false diagnosis of hyperprolactinemia due to interference in the measuring procedure. The aim was to develop a protocol that enables diagnosis of monomeric hyperprolactinemia, which should also be complementary to the procedure for detecting MPRL.
[Current Diagnosis and Treatment of Hyperprolactinemia]
It is published every 2 months 6 issues per year. All manuscripts are submitted for review by experts in the field peer review and are carried out anonymously double blind. The Journal accepts works written in Spanish or English. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more.
Hyperprolactinemia is a frequent problem in daily clinical practice.. There are several causes of hyperprolactinemia, the most common of which are medications. Consequently, a detailed history must be taken to guide diagnosis.. A thorough history and physical examination, routine laboratory investigations thyroid—stimulatinghormone determination, and pregnancy test allow can rule out all causes of hyperprolactinemia except hypothalamus-pituitary disease..