ALKERAN PACKAGE INSERT PDF

Melphalan is a chemotherapy drug designed to slow the growth of and kill multiple myeloma cancer cells. Melphalan is given to kill residual left over multiple myeloma cells, decrease the amount of abnormal blood protein produced by myeloma cells, prevent relapse, and increase survival. Patients who are fit may receive this type of stem cell transplant on an outpatient basis with close monitoring in clinic. In a multi-drug regimen, each medication has unique side effects.

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Melphalan is a chemotherapy drug designed to slow the growth of and kill multiple myeloma cancer cells. Melphalan is given to kill residual left over multiple myeloma cells, decrease the amount of abnormal blood protein produced by myeloma cells, prevent relapse, and increase survival.

Patients who are fit may receive this type of stem cell transplant on an outpatient basis with close monitoring in clinic. In a multi-drug regimen, each medication has unique side effects. When these medicines are given together, drug-related side effects reported in clinical studies give the best estimate of what to expect. In clinical studies , the most commonly reported side effects of melphalan are shown here.

Diarrhea may also be more common in elderly patients. Labs blood tests may be checked before treatment, then daily or every other day for the first few weeks while in the hospital, and then periodically after hospital discharge.

A chest x-ray or chest CT scan may be needed if an infection such as pneumonia is suspected during hospitalization. An ultrasound may be performed to evaluate for formation of a clot during treatment. An EKG may be recommended if you feel a very fast heartbeat to look for atrial fibrillation. Daily or every other day labs will indicate bone marrow recovery after transplant. During this time mouth sores tend to heal, nausea and vomiting decrease, antimicrobial prevention agents are discontinued and the patient is prepared for discharge in the following days.

Depending upon your income, they may be able to help cover the cost of:. For Branded medications may be available for generic medications too , check with the manufacturer to determine if a co-pay card is offered and if it could reduce your monthly copay.

What is Emotional Wellness? Emotional wellness is having a positive outlook balanced with a realistic understanding of current life events. This requires both an awareness and acceptance of your emotions. It is with this knowledge that you can develop a plan to take the necessary actions to positively impact your life.

Emotional wellness uses an ongoing process to continually reflect on the stressors of life in a constructive manner to move forward and create happiness. Because emotional wellness is deeply connected with physical, social, and spiritual wellness, pursuing it often becomes particularly difficult in times of major illness. Despite this difficulty, working toward emotional wellness has been connected to improved treatment outcomes and a higher likelihood of achieving goals of therapy.

Bone Marrow Transplant. High-dose melphalan and autologous bone marrow transplantation as consolidation in previously untreated myeloma. J Clin Oncol. Biol Blood Marrow Transplant. An elective single autograft with high-dose melphalan: single-center study of patients. How I treat myeloma with new agents. High-dose chemotherapy is designed to kill more cancer cells, but it also destroys normal blood-producing cells in the bone marrow.

A conditioning regimen is a form of treatment used to prepare a patient for stem cell transplant. The conditioning regimen is used to make room in the bone marrow for new white blood cells, red blood cells and platelets to grow, helps eliminate or kill any residual cancer cells, and ensures that the body does not reject the newly infused stem cells.

It may include chemotherapy, monoclonal antibody therapy, total body irradiation, or a combination of these. A Complete Blood Count CBC is a frequently ordered blood test that tells clinicians the status of your: 1 White blood cell count, 2 Hemoglobin, and 3 Platelet count at the time the test was taken. Common uses: 1 White blood cell count WBC : is used to determine infection risk, or response to chemotherapy.

Certain chemotherapy agents may harm our good infection-fighting cells. Sometimes chemotherapy may need to be delayed to allow these cells to recover. Red blood cell transfusions, and sometimes iron can be given to restore the hemoglobin level, but anemia treatment should always aim at treating the underlying cause or condition. Certain medications that increase bleeding risk, such as: aspirin, certain chemotherapy agents, and blood thinners, may need to be stopped temporarily until the platelet count is within a safe range.

It is commonly used to monitor liver and kidney function when beginning new medications such as chemotherapy. A total of 14 tests are run simultaneously and are shown below. Engraftment is when the new blood-producing cells start to multiply in the bone marrow and begin to appear the blood.

White blood cell engraftment usually occurs first, prior to platelet or red blood cell engraftment, and is associated with the healing of mouth sores, resolution or abatement of nausea and neutropenic fever. Patients can go home from the hospital soon after engraftment occurs. Total Parenteral Nutrition TPN is the process of administering a type of liquid nutrition intravenously, bypassing the normal process of food digestion in stomach and gastrointestinal tract.

It frequently consists of glucose, lipids, amino acids, electrolytes, vitamins, and minerals and is given to people who cannot eat due to mucositis or cannot absorb nutrients due to inflammation of the colon.

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Product Profile

Teva's generic medications are available in most pharmacies across the United States, though not all pharmacies carry the same Teva medications. To find out if your medication is available as a Teva generic, contact your local pharmacy. If the pharmacy doesn't regularly stock a certain medication from Teva, ask if it can be ordered for you at no additional cost. The product catalog provides you with a full listing of Teva's brand and generic product lines. The catalog displays all strengths and sizes along with the description, imprint code, NDC and photo for each product. We will not share your email or personal information.

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Melphalan Hydrochloride for Injection

One vial of ALKERAN for injection containing sterile, nonpyrogenic, freeze-dried melphalan hydrochloride equivalent to 50 mg melphalan and 20 mg povidone. One vial of sterile, nonpyrogenic diluent containing 0. Reconstitute with enclosed diluent. See enclosed package insert for additional reconstitution and administration instructions.

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